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Plasma concentrations remained minimal, even at high doses, with most curcumin localized in the small intestine and little reaching systemic circulation, resulting in a bioavailability of approximately 1% (71, 90, 92)

Modulation of lipid peroxidation and mitochondrial function improves neuropathology in Huntingtons disease mice

[3] [5] Topical application also keeps the copper load overwhelmingly local: intact stratum corneum is a substantial barrier to a ~403 Da charged metal complex, which limits systemic copper exposure the same barrier property that limits topical efficacy is what limits topical copper risk

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