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Acknowledgments The authors would like to thank all subjects who participated in this study
The peptide is a disulfide-cyclized octamer and is reported to have agonist activity on both hMC3R (EC 50 = 1.61 nM, E max = 84%) and hMC4R (EC 50 = 0.280 nM, E max = 95%) as shown in Table 1 (52)
More recent trials have examined the effects and superiority of agents that exhibit both long-acting glucose-dependent insulinotropic polypeptide (GIP) and GLP1 receptor agonism
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