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ERRs are members of the nuclear receptor superfamily of ligand-activated transcription factors, though unlike most nuclear receptors, ERRs are constitutively active and were long thought to be "orphan" receptors lacking endogenous ligands

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This multidisciplinary approach, which addresses both the biological and physical dimensions of tissue healing, ensures that each aspect of the regenerative processfrom cellular signaling and extracellular matrix remodeling to the mechanical environmentis holistically managed, providing an advanced strategy for medical treatment and rehabilitation