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292,334,335 Thus, the expression of pro-angiogenic factors such as VEGF-A isoform 164 is repressed, and the expression of dys-angiogenic factors such as VEGF-A isoforms 120 and 188 is increased, causing capillary rarefaction

The authors concluded that the senescent microenvironment maintained by SASP and p53-pS15 signalling promotes keloid aggressiveness and relapse, and that FOXO4-DRI targets this mechanism selectively

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