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The Pharmaceutical Response: DPP-4 Inhibitors The pharmaceutical industry recognized this limitation and developed DPP-4 inhibitor drugsmedications like sitagliptin (Januvia), saxagliptin (Onglyza), and linagliptin (Tradjenta)

While there is also a six-month bundle for semaglutide, there is no monthly billing option for either semaglutide or tirzepatide

Conclusions This narrative review demonstrates that semaglutides oral adverse effects cannot yet be explained by direct salivary-gland data, but the convergence of three mechanistic domainsalbumin-mediated continuous receptor stimulation, bias toward sustained Gs/cAMP signaling, and -arrestindependent desensitizationprovides a coherent hypothesis for salivary hypofunction