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4.3 Potential effects of gut metabolites on ferroptosis in OA 4.3.1 Gut metabolites inhibiting ferroptosis mechanisms 4.3.1.1 Tryptophan metabolites suppress ferroptosis via antioxidant mechanisms Tryptophan metabolites serve as pivotal mediators in host-microbiota interactions and are closely linked to systemic inflammatory and immune processes (Gaspar et al., 2025)
ANTIOXIDANT AND ANTI-AGING Glutathione is a powerful free radical scavenger and it is essential for the regeneration of other antioxidants such as tocopherol (Vitamin E) and ascorbate (Vitamin C)
These results represent the most detailed description of the catalytic reduction mechanism of OsDHAR at atomic resolution and are fully consistent with all available biochemical data (Fig
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