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The major causes fall into three broad categories: Increased bilirubin production (hemolysis or ineffective erythropoiesis): Hemolytic anemias (intravascular or extravascular) Autoimmune hemolytic anemia (AIHA) Hereditary spherocytosis, elliptocytosis G6PD deficiency Sickle cell disease Thalassemia Ineffective erythropoiesis Vitamin B12 or folate deficiency (megaloblastic anemia) Myelodysplastic syndromes Thalassemia major Impaired hepatic uptake : Gilbert syndrome decreased activity of UDP-glucuronosyltransferase (UGT1A1)

Goldenberg RL, Rouse DJ

Modulation of host cell signaling pathways as a therapeutic approach in periodontal disease

Furthermore, IGF-1 stimulates the proliferation of myoblasts, thus causing an increase in muscle cells