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Initial studies had indicated DPP-4 to be an adipokine due to its release from the adipocyte membrane through the action of matrix metallopeptidase 9 (MMP9), resulting in the release of the soluble DPP-4 form in the circulation [35]

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Current treatment guidelines support the use of methylcobalamin (MC), a methylated derivative of vitamin B 12 which also demonstrates efficacy in improving nerve conduction and reducing neuropathic pain 9 , but thus far, the clinical value of MC has not been studied in comparison to ALC

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