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single-route administration (e.g., intracerebroventricular-only) restricts cellular engraftment to periventricular regions, neglecting peripheral immunomodulatory effects

A highly distinctive pattern of labial, perioral and acral macular pigmentation represents one of the earliest clinical manifestations of this disease (Figure 5)

Calcidiol is the major form of vitamin D found in the circulation and is transported in the blood bound to the vitamin D-binding protein encoded by the GC gene

Comprehensive molecular genetic studies use DNA from blood cells to search for patterns for analysis to establish if a full sibling of the affected patient is a carrier of the WD gene[4]