why am i not losing weight in semaglutide on Semaglutide? I lost 25 pounds in

In PD, mitochondrial ROS and electrophilic metabolites modify specific cysteine residues on Keap1, altering its ability to target Nrf2 for degradation

I think it's worth taking seriously as a hypothesis, but the honest framing is that we don't have the clinical endpoints yet

The 200% GLP-1 increase claim, while possibly accurate in percentage terms, obscures the fundamental limitation that natural GLP-1 degrades in minutes while pharmaceutical alternatives act for days

They investigated the relationship between intestinal flora imbalance and severe MASLD lesions (MASH and fibrosis) and showed that an increase in the number of Ruminococcus was positively associated with an aggravation of the degree of fibrosis (76)