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In addition to its activity against hyperglycemia, DPP-4i has shown beneficial cardiovascular effects including cardioprotective action, endothelial protection, and an anti-hypertensive effect

Tirzepatide is the older, fully matured story: a single-molecule dual incretin agonist taken from discovery through Phase 1 proof-of-concept, [7] then through the large SURPASS (diabetes) and SURMOUNT (obesity) Phase 3 programs, and finally to FDA and EMA approval

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Finally, the FDA warned a Georgia company selling herbal supplements that claim to support glucose management, lower blood pressure, and treat arthritis pain for selling misbranded and unapproved new drugs