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More commonly, Rybelsus is used as combination therapy alongside other glucose-lowering medications, including: Metformin the first-line treatment for type 2 diabetes Sulfonylureas though this combination may increase hypoglycaemia risk Sodium-glucose co-transporter-2 (SGLT2) inhibitors Insulin when additional glycaemic control is required Before prescribing Rybelsus, healthcare professionals will assess several factors, including current HbA1c levels, body mass index (BMI), cardiovascular risk profile, kidney function, and previous medication history

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