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The outer abdomen, particularly the lower quadrants, contains substantial fat even in relatively lean individuals

Summary: Cagrilintide and retatrutide are investigational injectable medicines being studied for obesity and type 2 diabetes in men, targeting multiple hormonal pathways to reduce appetite, improve blood glucose control, and increase energy expenditure, but neither is currently licensed in the UK

For this reason, DSIP is most often studied in the context of sleep architecture, stress regulation, and neuroendocrine balance rather than as a pure sleep-onset agent