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Thus, following the identification of active BAT in adult humans and the demonstration that certain depots of white adipose tissue can undergo browning, there has been recent interest in the development of approaches that induce BAT activity and promote browning [10]

And this is where its really important to know where these patients came from

Second, a long lapse : if weeks pass without a dose, the tolerability that was built up erodes, and the documented conservative approach is to re-initiate lower rather than resume at the last dose reached

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