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Separate 12-week clinical studies by Leyden et al

CJC-1295 binds to GHRH receptors, increasing the baseline signal for growth hormone production Ipamorelin binds to ghrelin receptors, amplifying the pulse on top of CJC-1295's baseline elevation When both pathways are activated simultaneously, the growth hormone response is significantly greater than either peptide alone a true synergistic effect, not merely additive

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These findings suggest that calcium and vitamin D act synergistically to regulate reproductive and metabolic systems, ultimately benefiting women with PCOS [143]