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This complex process means that conditions affecting the stomach or intestines can significantly impair B12 absorption, including pernicious anaemia, atrophic gastritis, previous gastric surgery, coeliac disease, Crohn's disease, and long-term use of certain medications (such as metformin, proton pump inhibitors, and H2 antagonists)

A small 2010 study published in the Journal of the International Society of Sports Nutrition found the following: Forty-four men and women supplemented with either four grams of safflower oil or four grams of fish oil

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