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Atherosclerosis Statin therapy produces an estimated: 60% in the number of cardiac events 17% in stroke Greater benefit with high-intensity statins Familial hypercholesterolemia Familial hypercholesterolemia Lipid Disorders (FH) Genetic disorder that causes a loss of function Loss of Function Inflammation of the LDL receptor Receptor Receptors are proteins located either on the surface of or within a cell that can bind to signaling molecules known as ligands (e.g., hormones) and cause some type of response within the cell