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On the other hand, NPW treatment depressed the degree of lipid peroxidation, neutrophil infiltration and pro-inflammatory cytokine levels, and elevated antioxidant capacity in conjunction with the downregulation of gastric COX-1 and COX-2 mRNA levels, suggesting that improved gastric damage due to NPW could be eliminating the need for compensatory upregulation of COX enzymes

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While both peptides have been studied for tissue-regenerative properties, they appear to function through different mechanisms: BPC-157 may work primarily through growth factor-mediated pathways and nitric oxide systems

doi: 10.1016/j.phrs.2017.10.003 5 LauKSrivatsavVRizwanANashedALiuRShenRet al