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These include new sequences for optimizing ovarian reserve, follicular response in ART, and delaying age-related hormonal decline
They need not go quite as far as men, however
BMS-754807 is a potent IGF-1R inhibitor, which has been reported to have a limited off-target effect since the transcriptional profile is similar between wild-type MEF cells treated with BMS-754807 and IGF-1R null MEF cells
The problem with acquired resistance is that tumors not only become resistant to the drugs originally used in treatment, but also become cross-resistant to other drugs
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