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MET-097i is described as a "fully-biased" GLP-1 agonist, which may influence signaling pathway selectivity

AOD-9604, sometimes called the fat-burning peptide, showed limited promise in animal studies but has failed to demonstrate consistent results in people, leading the FDA to explicitly state it is not an approved treatment (FDA on unapproved drugs)

There has not yet been a consensus drawn as to whether the most reasonable approach would be to continue these medications perioperatively while altering ones diet, although some studies have suggested this as a definitive option (Midler et al

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