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McDonald I, Connolly M, Tobin AM

Our findings highlight that certain loci appear shared across ancestries, whereas others are distinct or attenuated in multi-ancestry analyses, suggesting that population-specific genetic architecture contributes meaningfully to POAG susceptibility

This strategy suits users who plateau after several months suggesting diminishing returns, want to minimize long-term costs while maintaining some benefits, prefer avoiding indefinite commitments to any treatment, notice maintained improvements during initial breaks suggesting cycling viability, and value flexibility over maximum continuous optimization