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Furthermore, VEGF may also increase the permeability of blood vessels, which might enable the extravasation of plasma proteins and contribute to the formation of a primitive vascular scaffold, thereby potentially promoting the process of angiogenesis
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This interacts with the HPA axis your body's central stress-response system in a straightforward way: when you're physically exhausted and neurologically compromised, cortisol stays elevated longer, recovery from stressful events takes more time, and the subjective experience of stress intensifies
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