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Most existing investigations tend to focus on either small peptides or larger bioactive peptides independently, resulting in limited data on their relative efficacy, mechanistic differences, and potential synergistic applications within the same experimental frameworks

doi: 10.3389/fphar.2025.1586231 Received 21 March 2025 Accepted 30 April 2025 Published 09 June 2025 Volume 16 - 2025 Edited by Irwin Rose Alencar de Menezes, Regional University of Cariri, Brazil Reviewed by Alaaeldin Ahmed Hamza, National Organization for Drug Control and Research (NODCAR), Egypt Mohannad A

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In addition, ROS may amplify the inflammation process by gene involved in the inflammatory response, particularly via activation of the nuclear transcription factor NF-k, which in turn up regulates pro-inflammatory cytokines and leukocyte adhesion molecules