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This is a Fenton-adjacent reaction: the reduced copper(I) then reacts with any hydrogen peroxide present (generated enzymatically at the skin surface) to produce hydroxyl radicals, among the most damaging reactive oxygen species in biology

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COVID-19 in conjunction with diabetes and obesity (both characterized by severe insulin resistance) has severe clinical consequences 742,743

No participants developed antibodies against AOD-9604, and no treatment-related serious adverse events led to study withdrawal