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Transcriptional repression by YY1 is mediated by interaction with a mammalian homolog of the yeast global regulator RPD3

The FDA approved it in June 2021 specifically for chronic weight management making it one of the first GLP-1 receptor agonists with an explicit obesity indication rather than just a diabetes label

La fixation du smaglutide sur les rcepteurs de GLP1 aurait donc une action similaire celle de GLP1 en inhibant la production de glucagon

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