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This case implies that the melanosis pigment-laden macrophages formed in the lamina propria of the colon pass to the regional lymph nodes and may explain the observation of similar pigment-laden macrophages in other sites

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These findings will be revisited in the Therapeutic Strategies section, but mechanistically they underscore that DAMPsening the mtDAMPs-innate receptor axis is a viable approach to reduce surgical organ damage

Learn more (As always, timelines can shift with FDA review and manufacturing readiness.) What the new mechanism is: The mechanism is still GLP-1 receptor activation, but the innovation is the delivery technology (oral small molecule) a major change in how GLP-1 therapy may be taken