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Clinical studies show adequate choline intake lowers liver enzyme levels and improves hepatic insulin sensitivity, both markers of improved liver function and metabolic health

Neuroinflammation in ME/CFS was initially suggested by studies showing elevated levels of pro-inflammatory cytokines, and decreased anti-inflammatory cytokines, in cerebrospinal fluid from lumbar punctures in ME/CFS patients [62, 63], and further supported by a positron emission tomography (PET) study [64], which showed increased binding of a radioligand to 18 kDa translocator protein (TSPO) receptor, the expression of which increases when microglia are activated

The mechanism enhanced phospholipid turnover and methyl donor availability operates continuously but produces gradual rather than acute effects

This suggests that maintaining optimal glutathione levels may contribute to healthy aging