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When ligands bind to their receptors, they cause JAK phosphorylation, which then stimulates STAT phosphorylation, which subsequently controls the transcription of target genes which produce chemokines and pro-inflammatory cytokines (Villarino et al

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It's particularly well-suited if you're looking for an evidence-based active for mature or ageing skin, want a fragrance-free formulation without unnecessary additives, are interested in supporting your skin's own renewal processes over time, or have had reactions to heavily fragranced or complex serums and want something cleaner