taking tirzepatide and retatrutide together vs. Tirzepatide: What's The Difference? – Forbes Health Retatrutide vs Tirzepatide vs Semaglutide

Reported incidences in those receiving a 12mg/weekly dose of retatrutide were [21]: Nausea (45% of participants) Vomiting (19%) Constipation (16%) Diarrhea (15%) Cardiac arrhythmia (11%) Fatigue (10%) Increased pancreatic enzyme (lipase) levels (8%) Injection site reactions (8%) Liver issues in 2 participants (3%) Pancreatitis in 1 participant (2%) Both tirzepatide and retatrutide share similar contraindications, including advice against their use during pregnancy and breastfeeding

In pharmacology, steady state is typically reached after 4 to 5 half-lives

No speculation

Moreover, GLP-1 upregulated BV2 microglia cells expression of BDNF in a PKA-dependent manner (184)