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277 The estimated number of people age 65 and older with clinical Alzheimer's dementia comes from an updated study using the Chicago Health and Aging Project (CHAP), a populationbased study of chronic health conditions of older people, and the latest data from the 2024 population projections from the U.S

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In the cells, the imbalance between production/elimination of free radicals (oxygen radicals and other reactive oxygen species (ROS)) leads to oxidative stress which causes detrimental damages to the macromolecules and vital structures in biological systems [9, 10]