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Watch the full conversation on YouTube Listen now When I pushed Layne on what actually works long-term, he gave me a concrete list: they pick a sustainable plan they can still follow when life gets hard, they self-monitor by weighing in regularly as a feedback loop, they eat meals instead of snacking, they use some form of deliberate restraint like tracking macros or an eating window, and they exercise not to burn calories, but to stay sensitive to satiety signals

Borner T, Geisler CE, Fortin SM, et al

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Most cells contain numerous SAMe-dependent methyltransferases that can transfer the methyl group (CH 3 ) to all varieties of key substrates, for example nucleic acid, protein, phospholipids, and monoamine neurotransmitters [4]