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Moiz and colleagues found that retatrutide 12 mg weekly (Eli Lilly) showed the greatest effect on obesity among all agents in the review, producing weight loss of up to 22.1% (95% CI, 19.3%-24.9%) after 48 weeks of treatment

The amount of muscle lost in most people who take GLP-1 drugs is similar to whats seen in people who lose weight through diet alone, and in both cases it can be minimized with balanced food choices and exercise (more on that below)

Dr Sarah Bennett, registered nutritionist and senior research associate at Slimming World, breaks down what it is, how it works and how it fits into everyday healthy eating

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