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Classical acyltransferases (KAT family) and deacylases (HDAC and SIRT family) are believed to catalyze all lactylation modifications and delactylation processes, but several non-classical acyltransferases are also included, such as AARS1, AARS2 (Fig

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Amino acids metabolism Amino acid metabolism in cellular functions Amino acids, traditionally recognized as the fundamental components of protein biosynthesis, also play versatile roles as precursors for enzymes, signaling molecules, and essential metabolic intermediates that support cellular homeostasis and tissue remodeling [8, 47, 48]