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BMI Reduction: Participants receiving liraglutide achieved a mean BMI reduction of 4.3%, compared with a 0.3% reduction observed in the placebo group

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BMG LABTECH)

However, it should be emphasized that use of caloric restriction to control for weight-dependent effects in DIO mouse studies may potentially introduce confounding effects on microbiome signatures due to significant compensatory changes in hunger sensation, feeding pattern, resting metabolic rate and gut morphology which may be disproportionately to that attained by appetite suppressants 80,81