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We analyzed the relationship between the expression of RAPGEF3 and RAPGEF4 mRNA and disease-free survival (DFS) in patients diagnosed with primary melanoma based on high (median) and low (median) levels of both RAPGEF3 and RAPGEF4 to assess the cumulative effect of these two genes on DFS [27]

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Superoxide dismutase is the body's first line of enzymatic defense against intracellular free radical production through reduction of one-electron dismutation of oxygen (O 2 - ) to hydrogen peroxide (H 2 O 2 ) [10]