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sinensis (and other DSS herbs), modulates multiple metabolic pathwayssuch as PI3K/AKT, PPAR, MAPK, AMPK, and the insulin signaling pathwayto regulate glucoselipid metabolism and hormone levels, thereby contributing to the alleviation of PCOS ( Emerging evidence indicates that the gut-brain axis orchestrates bidirectional communication through microbial-host co-metabolism, wherein commensal Bacteroides convert dietary tryptophan into neuroactive metabolites such as indole-3-propionic acid (IPA) and serotonin (5-HT)

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