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Six weeks of hypoxic treadmill exercise significantly increases Sirt3 expression in the skeletal muscle of C57BL/6J mice, followed by upregulating the levels of FOXO3a, SOD2, PINK1, and Parkin proteins, with no significant change in the expression of Drp1 proteins, which promotes the level of mitophagy, and consequently improves the synthesis of ATP and the activity of citrate synthase (CS) in the skeletal muscles and increases mitochondrial volume and number

27 ) was utilized to compare gene expression across three distinct pair-wise tissue contrasts

There isnt a single straightforward answer, but one contributing factor is something called leaky gut

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