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M., Aebischer, P., Rinsch, C., Singh, A., & Marcinek, D

NF1 Status: Patients with NF1-associated MPNST have a poorer prognosis than sporadic cases, with higher rates of recurrence and lower response to chemotherapy (Reuss et al., 2020)

The melanocytomas that arise within this pathway harbor secondary mutations that activate protein kinase A ( PRKAR1A - inactivated melanocytoma) or the beta-catenin pathway (deep penetrating or beta-catenin-activated melanocytoma) or perturb the epigenetic state of the genome ( BAP1 -inactivated melanocytoma)