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Liver metabolism during glucouronidation or sulfation, CYP activity and maintenance of hepatic GSH supply depends on patient factors such as age, nutritional status, pre-existing liver disease, concurrent use of alcohol and other liver-metabolized medications, genetic predispositions, and most importantly, the acuity or chronicity of APAP overuse.3,15,17,2030 Table 1

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2.2 Intake of vitamin E through supplementation It is clear from the above that with a normal diet it is not possible to have too high an intake of vitamin E to cause adverse effects

Development of human pluripotent stem cell-derived hepatic organoids as an alternative model for drug safety assessment