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Endothelial dysfunction: molecular mechanisms and clinical implications

[PMC free article: PMC8729835] [PubMed: 34272327] 190

10.1111/acel.12880 105 KreouziM.TheodorakisN.ConstantinouC

Whilst a handful of enterovirus vaccines are available, including for poliovirus (PV) and for EV-A71 (frequently responsible for serious outcomes of hand, foot and mouth disease) 1,2,3,4 , there are as yet no licenced anti-enterovirus drugs, despite evidence for efficacy in clinical trials and reports of extremely high potency for compounds targeting a pocket internal to capsid protein VP1 (termed here the P site) 5,6