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The valleys between papillae show mild acanthosis and are filled with keratotic material

Oh et al., 2013)

Studies have shown significantly reduced GPX3 mRNA levels in chondrocytes from KBD patients, where elevated methylation of CpGs in the GPX3 gene suppresses its transcription, reducing antioxidant function and promoting chondrocyte apoptosis, thus accelerating KBD progression [205,206]

when it is inhibited, neurons quickly restore glutamate neurotransmission by an ill-defined endogenous mechanism, suggesting that neurons might be making use of a storage buffer of glutamate (15)