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4.1 Gut microbiota and BBB BBB breakdown is an early pathological event in MS, occurring before lesion formation and in normal-appearing white matter, alongside pathogenic immune cell infiltration

The prefrontal cortex is highly sensitive to DA and even minor fluctuations can impair prefrontal cortex-dependent functions, making it particularly relevant in PTSD, as it plays a central role in suppressing fear responses, regulating stress reactivity, and enabling emotional control (Cools and D'Esposito, 2011)