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In situations where there is severe liver injury or fulminant hepatic failure, extensive loss of hepatocytes may result in decreased release of aminotransferases into the bloodstream, leading to subnormal serum levels of these enzymes

Jarosiewicz M, Michaowicz J, Bukowska B

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Functional heterogeneity expresses itself via differences in metabolism, oxygen supply, b-oxidation, amino acid metabolism, gluconeogenesis, glycolysis, ureagenesis, liponeogenesis, and bile acid and bilirubin secretion