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Early researchers noticed that GLP-1 powerfully and appropriately stimulated insulin only when glucose levels were high, meaning it lowered blood sugar without causing dangerous hypoglycemia, says New York internist and longevity expert Amanda Kahn, MD

Although stroke was not a primary outcome in RCT that assessed the effect of GPL1RA in high-risk patients, subgroup analyses of several CVOTs suggest that these medications may reduce the risk of cerebrovascular injury

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