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Limitations and research gaps: Because this work is a synthesis of available studies, conclusions are constrained by limitations in the underlying literature, most notably variability in inoculation/phenotyping protocols, uneven multi-location validation, limited functional validation of candidate genes in sesame, and incomplete characterization of pathogen diversity and genotype environment interactions (especially drought)

Even though parenteral glutathione is approved only for severe liver disorders and for prevention of chemotherapy associated neurotoxicity, the lack of statutory laws governing the use of systemic glutathione in most countries has contributed to its unchecked use for skin lightening

Compounded DHEAboth oral and vaginalfills a gap for genitourinary symptoms and broader adrenal support

Clinical work shows that even modest daily doses can reduce hyperpigmentation, even out skin tone, and soften fine lines