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Its main actions include: Stimulating insulin secretion from pancreatic beta cells in a glucose-dependent manner Suppressing glucagon release, which reduces hepatic glucose production Slowing gastric emptying, which moderates post-meal glucose spikes Promoting satiety through central nervous system pathways, thereby reducing appetite GIP is released by K-cells in the proximal small intestine and shares some functions with GLP-1, particularly in enhancing insulin secretion after meals
Some patients still benefit from B12 shots and benefits like steadier energy across the day, especially if intake has dropped alongside appetite
Importantly, human trials to date have primarily focused on hormone release rather than direct weight loss outcomes
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